首页|基于总评归一化法结合响应面设计优化祛寒逐风颗粒醇沉工艺

基于总评归一化法结合响应面设计优化祛寒逐风颗粒醇沉工艺

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目的 优化祛寒逐风颗粒的醇沉工艺.方法 以醇沉终点乙醇体积分数、浓缩液相对密度、醇沉时间为考察因素,以秦艽中龙胆苦苷含量、威灵仙中齐墩果酸含量、干膏率3个指标的总评归一值(Z值)为评价指标,采用星点设计-响应面法优化醇沉工艺.结果 祛寒逐风颗粒最佳醇沉工艺为:浓缩液相对密度1.08g/ml(90～95℃),醇沉终点乙醇体积分数为62％,静置16 h.结论 采用总评归一化法结合响应面设计优选的醇沉工艺稳定可行,预测性良好,可为其规模化生产提供依据.
Optimization of alcohol precipitation process for Quhan Zhufeng Granules by overall desirability and central composite design
Objective To optimize the alcohol precipitation process of Quhan Zhufeng Granules.Methods Taking the volume fraction of ethanol,the relative density of the concentrated solution and the standing time as the investigation factors,the Z value of the total evaluation of gentiopicrin content,oleanolic acid content and dry paste yield of gentiana macrophylla as the evaluation indexes,the star-point design-response surface method was used to optimize the alcohol precipitation process.Results The optimal the alcohol precipitation process of Quhan Zhufeng Granules:concentration relative density 1.08 g/ml(90-95 ℃),alcohol precipitation at the end of volume fraction of 62％ethanol,standing for 16 h.Conclusion The alcohol precipitation process using overall desirability and central composite design is stable and feasible,and has good predictability,which can provide experimental basis for further scale production.

Technology improving(TCD)Quhan Zhufeng GranulesGentiopicrosideOleanolic AcidOverall desirabilityCentral composite design

甄世福、张志瑞、毕映燕、李季文、李喜香

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甘肃省中医院药学部,兰州 730050

中药工艺改进 祛寒逐风颗粒 龙胆苦苷 齐墩果酸 总评归一值 星点设计

中央转移支付医疗服务与保障能力提升(中医药事业传承与发展部分)中医药人才培养重点学科建设项目甘肃省中医药科研项目

甘财社[2022]48号[2022]48

2024

10.3760/cma.j.cn115398-20231110-00118

国际中医中药杂志
中华医学会,中国中医科学院中医药信息研究所

国际中医中药杂志

CSTPCD
影响因子：0.411
ISSN：1673-4246
年,卷(期)：2024.46(4)
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