目的 探讨开心散的研究现状及热点.方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)、PubMed及Web of Science建库至2023年1月10日发表的开心散研究文献.采用CiteSpace 6.2.R2和VOSviewer 1.6.16软件对纳入文献的文献类型、来源期刊、发文量、作者、机构、关键词等数据进行可视化分析.结果 纳入文献235篇,以中文期刊论文为主,涉及来源期刊87种,其中《中国中药杂志》和J.Ethnopharmacol发文较多.开心散年发文量整体呈上升趋势,涉及505位作者,形成了以刘屏、姜艳艳等为核心的研究团队;纳入文献作者来自99家研究机构,机构间的合作以地理区域相同和相近单位、中医药大学及其附属医院为主;关键词共现聚类网络、关键词共现时间网络和关键词突现分析结果表明,开心散主要活性成分组成(人参皂苷类、茯苓酸、细辛醚类、酮类和寡糖酯类)、检测方法(HPLC及液质联用)、开心散药理作用(抗老年痴呆、抗抑郁)、作用机制及临床应用是当前研究热点和发展动向.结论 开心散的研究多集中于AD、抑郁症等疾病作用机制和临床研究,其中开心散主要活性成分研究是近年热点内容,而药理作用机制及临床应用等发展趋势较好,基于组方活性成分与功效相关性可能成为开心散研究新的热点方向.
Visualization analysis of research status and hotspots of Kaixin Powder based on VOSviewer and CiteSpace
Objective To discuss the research status and hotspots of Kaixin Powder.Methods Literature about Kaixin Powder was retrieved from CNKI,Wanfang Data,VIP,CBM,PubMed and Web of Science databases from the establishment of the databases to January 10,2023.CiteSpace 6.2.R2 and VOSviewer 1.6.16 software were used to visualize and analyze data on the types of literature included,source journals,publication volume,authors,institutions,keywords,etc.Results Totally 235 articles were included,mainly Chinese journal article.There were 87 source journals involved,among the Chinese and English journals,China Journal of Chinese Materia Medica and J Ethnopharmacol published the most articles.The overall annual number of articles published in the Kaixin Powder showed an upward trend.It involved 505 authors,forming research teams with Liu Ping,Jiang Yanyan and others as the core;The authors of the included literature came from 99 research institutions,and the cooperation between institutions was mainly based on units with the same or similar geographical area,TCM universities and their affiliated hospitals.The data results of keyword co-occurrence clustering network,keyword co-occurrence time network and keyword emergence analysis showed that the composition of the main active components(ginsenosides,poria acid,fine octyl ethers,ketones and oligosaccharide esters),detection methods(high performance liquid chromatography and liquid chromatography-mass chromatography),pharmacological effects(anti-Alzheimer's disease,antidepressant),mechanism of action and clinical application of the combination were the current research hotspots and trends in development.Conclusion The research of Kaixin Powder mostly focuses on the mechanism of action and clinical research of Alzheimer's disease,depression and other diseases,among which the research on the main active components in Kaixin Powder is a hot topic in recent years,while the development trend of pharmacological mechanism of action and clinical application is better,and the correlation between active components and efficacy may become a new hot direction in the research of Kaixin Powder.
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