通腑法调节肠道菌群及修复肠黏膜屏障研究进展
Research progress in regulating intestinal flora structure and repairing intestinal mucosal barrier damage through Tongfu method
吴熠姮 1徐志伟 1朱惠萍 2俞嵩 2张川 2丁姮月 2孙宏文2
作者信息
- 1. 南京中医药大学,南京 210023
- 2. 南京中医药大学附属苏州市中医医院脾胃病科,苏州 215009
- 折叠
摘要
肠道菌群及肠屏障功能对于肠道功能及人体健康具有重要意义.肠道菌群紊乱、肠屏障结构被破坏,会导致体内细菌移位、内毒素入血、促炎性细胞因子产生,从而引发机体各种组织损伤.中医通腑法可通过调节肠道通透性及其免疫应答、恢复肠道正常运动、调节肠道菌群结构及其代谢产物等方面影响肠道内环境,从而维护肠稳态及机体健康.对通腑法调节肠道菌群、改善肠屏障功能开展相关研究,可为进一步研究中医药与肠道微生态的关系提供参考,并为临床治疗提供思路.
Abstract
The intestinal flora and gut barrier function are of great significance for gut function and human health.When the intestinal flora is disrupted and the gut barrier structure is disrupted,it can lead to bacterial translocation,endotoxin influx into the bloodstream,and the production of pro-inflammatory factors,leading to various tissue damage in the body.Tongfu method in TCM can affect the intestinal environment by regulating intestinal permeability and immune response,restoring normal intestinal movement,and regulating the structure and metabolites of intestinal flora,thereby maintaining intestinal homeostasis and body health.The research on regulating intestinal flora and improving intestinal barrier function by Tongfu method can provide reference for further research on the relationship between TCM and intestinal microecology,and provide ideas for clinical treatment.
关键词
中医药治法/通腑法/肠道菌群/肠黏膜屏障/肠屏障功能/综述Key words
Therapeutic methods(TCMP)/Tongfu method/Intestinal flora/Intestinal mucosal barrier/Intestinal barrier function/Review引用本文复制引用
基金项目
国家中医药管理局全国中医学术流派传承工作室第二轮建设项目(国中医药人教函[2019]62号)
江苏省科技项目(BK20201179)
苏州市"科教兴卫"青年科技项目(KJXW2021045)
苏州市卫生计生委科技项目(LCZX201817)
苏州市科技计划项目(SYS201777)
苏州市科技计划项目(SKY2022015)
苏州市科技计划项目(SS202082)
出版年
2024
NETL
NSTL
万方数据