Clinical study of Tongren Niuhuang Qingxin Pills combined with Telmisartan in the treatment of hypertensive vertigo syndrome of phlegm-heat disturbance
Objective To observe the clinical efficacy and safety of Tongren Niuhuang Qingxin Pills combined with telmisartan tablets in the treatment of hypertensive vertigo syndrome of phlegm-heat disturbance.Methods Randomized controlled trial was conducted.Totally 80 patients with hypertension vertigo and phlegm-heat disturbance syndrome were selected from March 2021 to August 2022 at Beijing Tongrentang Hospital of Traditional Chinese Medicine as the observation objects.They were randomly divided into two groups using a random number table method,with 40 cases in each group.The control group received oral telmisartan tablets,while the experimental group received Tongren Niuhuang Qingxin Pills in addition to the control group.Both groups were treated for 28 days and followed up for 1 month.The patients'room blood pressure before and after treatment was measured,and TCM syndrome scores were evaluated.The dizziness assessment rating scale(DARS)was used to evaluate the severity of dizziness,adverse reactions during treatment were recorded,drug safety was observed,and clinical efficacy was evaluated.Results The total effective rate of the experimental group was 85.0％(34/40),and that of the control group was 7.5％(3/40),with statistical significance between the two groups(χ2=48.32,P＜0.001).Compared with before treatment,the experimental group had SBP[(136.63±6.01)mmHg vs.(159.30±9.01)mmHg,t=-21.00]and DBP[(84.48±4.36)mmHg vs.(95.30±3.75)mmHg,t=-13.80]after treatment;after treatment,SBP[(137.34±6.39)mmHg vs.(158.00±10.06)mmHg,t=-5.28]and DBP[(86.08±4.43)mmHg vs.(95.18±6.61)mmHg,t=-8.09]decreased in the control group(P＜0.01),but there was no statistical significance between the two groups after treatment(P＞0.05).After treatment,the TCM syndrome scores in the experimental group(8.68± 3.39 vs.15.12±3.03,Z=-6.61)were lower than those in the control group(P＜0.001),and DARS score[(8.53±3.93)vs.(12.20±3.95),Z=-3.63]was lower than that in the control group(P＜0.001).After treatment,the therapeutic effect index of TCM syndromes in the experimental group improved compared to before treatment in the same group.The therapeutic effect index of each symptom,from high to low,was as follows:rotation of oneself or visual objects＞numbness of limbs＞dry stool＞dizziness and dizziness＞liking cold drinks＞bitter and dry mouth＞red urine＞red tongue,yellow coating,and greasy tongue＞vomiting sticky and turbid phlegm＞tinnitus＞smooth pulse.There were no significant adverse reactions during the treatment of the two groups.Conclusion Tongren Niuhuang Qingxin Pills combined with telmisartan can reduce the blood pressure of patients with hypertensive vertigo syndrome of phlegm-heat disturbance,improve the vertigo symptoms and TCM syndromes of patients,and the efficacy evaluation is superior to that of telmisartan alone.
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