牛膝干预骨质疏松症实验研究进展
Research progress in experimental study on the intervention of Achyranthis Bidentatae Radix in osteoporosis
吴秀丽 1阎晓霞 2任之强 2孙楠 2李金菊2
作者信息
- 1. 河南中医药大学,郑州 450000
- 2. 河南省洛阳正骨医院/河南省骨科医院骨病科,郑州 450000
- 折叠
摘要
对牛膝及其主要成分治疗骨质疏松症(OP)的作用机制研究文献进行综述,发现牛膝可通过促进骨髓间充质干细胞成骨分化、增强成骨细胞活性、抑制破骨细胞活性、调节雌激素水平,达到防治OP的作用,主要调控Wnt/β-catenin、Notch、PI3K/Akt等信号通路.牛膝治疗OP的作用机制表现出多成分、多靶点、多途径的特点.
Abstract
The research literature on the mechanism of Achyranthis Bidentatae Radix and its main components in the treatment of osteoporosis was reviewed.It was found that Achyranthis Bidentatae Radix could promote the osteogenic differentiation of bone marrow mesenchymal stem cells,enhance the activity of osteoblasts,inhibit the activity of osteoclasts,regulate estrogen levels,and achieve the effects of preventing and treating osteoporosis.It mainly regulates Wnt/β-catenin,Notch,PI3K/Akt and other signaling pathways.The mechanism of Achyranthis Bidentatae Radix in the treatment of OP shows the characteristics of multi-component,multi-target and multi-pathway.
关键词
骨质疏松/牛膝(中药)/实验研究/综述Key words
Osteoporosis/Achyranthes Bidentatae Radix(TCD)/Experimental study/Review引用本文复制引用
基金项目
河南省中医药科学研究专项(2022ZYD14)
出版年
2024
NETL
NSTL
万方数据