Objective To investigate the effects of external application of Sanying Plaster on the size of thyroid nodules and the states of depression and anxiety in patients with benign thyroid nodules.Methods A randomized controlled trial was conducted.A total of 120 patients with benign thyroid nodules from the outpatient clinic of the Department of Thyroid Diseases at Shanghai Traditional Chinese Medicine Hospital from June to December 2022 were selected as the subjects of the study.They were divided into two groups using the random number table method,with 60 patients in each group.The control group received lifestyle intervention treatment,while the treatment group received Sanying Ointment in addition to the treatment of the control group.Both groups were treated for 3 months.TCM syndrome scores were measured before and after treatment;the maximum diameter of thyroid nodules was measured using a color Doppler ultrasound transverse section;the quality of life was assessed using the short form 36(SF-36);the degree of anxiety and depression was evaluated using the self-rating anxiety scale(SAS)and the self-rating depression scale(SDS);adverse reactions during the treatment period were recorded,and the clinical efficacy was evaluated.Results During the treatment period,4 cases in the treatment group and 3 cases in the control group did not complete the treatment.Finally,56 cases in the treatment group and 57 cases in the control group entered the efficacy evaluation.The total effective rate of the treatment group was 71.4％(40/56),and that of the control group was 14.0％(8/57),with a statistically significant difference between the two groups(x2=26.82,P＜0.001).After treatment,the TCM syndrome score of the treatment group(10.02±3.65 vs.16.65±3.44,t=-10.24)was lower than that of the control group(P＜0.001);the maximum diameter of thyroid nodules[11.00(4.65,19.93)mm vs.15.00(7.15,28.50)mm,Z=-2.43]was lower than that of the control group(P＜0.05);the SF-36 score[121.83(117.00,130.00)vs.114.42(104.25,127.50),Z=-2.62]was higher than that of the control group(P＜0.01);the SDS(46.72±4.59 vs.57.02±5.99,t=14.80)and SAS(42.25±5.72 vs.50.60±7.12,t=10.04)scores were lower than those in the control group(P＜0.001).The incidence of adverse reactions during the treatment period in the treatment group was 3.5％(2/57),and no adverse reactions occurred in the control group.Conclusion The external application of Sanying Ointment helps to reduce the size of thyroid nodules in patients with benign thyroid nodules,improve the quality of life and anxiety and depression,and increase clinical efficacy with good safety.
关键词
甲状腺结节/散瘿膏/健康状况调查简表/焦虑自评量表/抑郁自评量表
Key words
Thyroid nodule/Sanying Ointment/Medical Outcomes Study Health Survey Short Form-36 Item/Self-Rating Anxiety Scale/Self-Rating Depression Scale
万方数据