Clinical study on the combination of Huolong Moxibustion and Shaofu Zhuyu Ointment acupoint application in the treatment of sequelae of pelvic inflammatory disease with cold coagulation and stasis syndrome
Objective To evaluate the clinical efficacy of Huolong moxibustion combined with Shaofu Zhuyu ointment acupoint application in the treatment of sequelae of pelvic inflammatory disease with cold coagulation and stasis syndrome.Methods Randomized controlled trial study was performed.102 patients with pelvic inflammatory disease in our hospital from June 2021 to June 2023 were selected as the observation subjects.They were divided into two groups according to random number table method,with 51 cases in each group.The control group was treated with conventional Western medicine therapy,with 10 days as one course of treatment,for a total of 3 courses of treatment.The observation group was treated with Huolong Moxibustion combined with Shaofu Zhuyu Ointment acupoint application,once every 3 days,with 5 sessions as a course of treatment,for a total of 3 menstrual cycles.TCM syndrome scores were performed before and after treatment;doppler ultrasound diagnostic instrument was used to detect the maximum systolic blood flow velocity(PSV),end diastolic blood flow velocity(EDV),pulsatile index(PI),and resistance index(RI)of the uterine artery;ELISA was used to detect levels of β-endorphin(β-EP),prostaglandin F2α(PGF2α),and serum substance P(SP).Adverse reactions during treatment were recorded,and clinical efficacy was evaluated.Results The total effective rate of the observation group was 92.16％(47/51),while that of the control group was 76.47％(39/51),the difference between the two groups was statistically significant(x2=4.74,P=0.029).After treatment,the observation group had lower abdominal pain refusal to press(1.76±0.45 vs.2.12±0.54,t=3.66),limb coldness and chills(1.85±0.47 vs.2.21±0.60,t=3.37),menstrual disorders(1.93±0.56 vs.2.31±0.58,t=3.37),tongue purple coating white score(2.04±0.55 vs.2.52±0.50,t=4.25)and total score(7.58±1.56 vs.9.16±1.92,t=4.56)than the control group(P＜0.01);the EDV[(18.86±3.65)cm/s vs.(14.45±3.51)cm/s,t=6.23]and PSV[(37.94±5.19)cm/s vs.(32.21±4.97)cm/s,t=5.70]of the uterine artery were higher than those in the control group(P＜0.01);the RI[(72.62±7.56)％vs.(78.31±6.58)％,t=4.05],PI[(41.94±5.90)％vs.(47.52±5.59)％,t=4.90]were lower than those in the control group(P＜0.01);the levels of β-EP[(49.86±5.87)μg/L vs.(55.41±5.91)μg/L,t=4.76],PGF2α[(71.94±8.13)μg/L vs.(78.21±8.97)μg/L,t=3.70],and SP[(19.12±3.98)μg/L vs.(22.34±3.81)μg/L,t=4.17]were lower than those in the control group(P＜0.05).The incidence of adverse reactions during treatment was 11.76％(6/51)in the observation group and 3.9％(2/51)in the control group,with no statistically significant difference between the two groups(x2=0.44,P=0.505).Conclusion The combination of Huolong Moxibustion and Shaofu Zhuyu Ointment acupoint application can effectively improve the microcirculation status of the uterine artery in patients with pelvic inflammatory disease sequelae of cold coagulation and blood stasis syndrome,reduce the level of pain factors,alleviate the main symptoms of patients,improve clinical efficacy,and have good safety.
Pelvic inflammatory diseaseBlood stasis due to coagulated coldHuolong moxibustionShaofu Zhuyu ointment acupoint applicationTraditional Chinese medicine therapy
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