国际中医中药杂志2024,Vol.46Issue(12) :1677-1680,封3.DOI:10.3760/cma.j.cn115398-20231125-00296

黄芪治疗缺血性卒中作用机制研究进展

Research progress in the mechanism of Astragali Radix in the treatment of ischemic stroke

金常鑫 李若冰 辜耀东 蒋希成
国际中医中药杂志2024,Vol.46Issue(12) :1677-1680,封3.DOI:10.3760/cma.j.cn115398-20231125-00296

黄芪治疗缺血性卒中作用机制研究进展

Research progress in the mechanism of Astragali Radix in the treatment of ischemic stroke

金常鑫 1李若冰 1辜耀东 1蒋希成1
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作者信息

  • 1. 黑龙江中医药大学基础医学院,哈尔滨 150000
  • 折叠

摘要

黄芪的有效成分及含黄芪成药与制剂可通过抗氧化应激、抑制细胞凋亡、保护血脑屏障、减轻炎症反应、抑制铁死亡、促进神经细胞再生和新血管生成等药理作用,发挥对脑组织的保护作用.黄芪治疗缺血性卒中的基础研究中,实验指标重复率较高,应加强信号通路及增加细胞类型等上游水平的研究,且基础研究应与临床研究达成有效衔接.

Abstract

The active components of Astragali Radix,its patent drugs and preparations can play a protective role on brain tissue through a variety of pharmacological effects such as anti-oxidative stress,inhibition of cell apoptosis,protection of blood-brain barrier,alleviation of inflammatory response,inhibition of ferroptosis,promotion of nerve cell regeneration and new angiogenesis.In the basic research of Astragali Radix in the treatment of ischemic stroke,the repetition rate of experimental indexes is high.The research on upstream levels such as signal pathway and cell type should be strengthened,and the basic research should be effectively connected with clinical research.

关键词

黄芪(中药)/缺血性脑卒中/脑缺血再灌注损伤/综述

Key words

Astragali Radix(TCD)/Ischemic stroke/Ischemia reperfusion injury/Review

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出版年

2024
国际中医中药杂志
中华医学会,中国中医科学院中医药信息研究所

国际中医中药杂志

CSTPCD
影响因子:0.411
ISSN:1673-4246
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