Advances in the treatment of autoimmune diseases with telitacicept
B cell and humoral immunity play an important role in the occurrence and development of autoimmune disease(AID).B cell activating factor(BAFF)and A proliferation-inducing ligand(APRIL)are necessary for the maintenance of B cell bank and humoral immunity.Telitacicept is a fusion protein of the Fc segment of APRIL and BAFF receptor transmembrane protein activator and immunoglobulin G,which can be used to treat AID.This article discussed the mechanism of action of telitacicept and its progress in the treatment of AID,including systemic lupus erythematosus,autoimmune nephropathy,neuromyelitis optica spectrum disorder and primary Sjogren's syndrome,in order to provide some reference for clinical use.
telitaciceptautoimmune diseasesoluble receptor fusion protein
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