Clinical effect of compound Yinqiaojiedu mixture combined with acupuncture on moderate acne heat-toxin accumulation syndrome and effect of peripheral blood inflammatory cytokines
Objective To observe the efficacy of compound Yinqiaojiedu mixture combined with acupuncture in treating moderate acne heat-toxin syndrome.Methods Patients with moderate acne heat-toxin syndrome were randomly divided into treatment group and control group,30 cases in each group.The treatment group was treated with compound Yinqiaojiedu mixture(twice a day,30 mL each time)combined with acupuncture clearance(once a week),and the control group was treated with minocycline hydrochloride(twice a day,50 mg each time).The skin lesion count,traditional Chinese medicine(TCM)syndrome score,dermatology life quality index(DLQI)and inflammatory cytokines in peripheral blood,including interleukin(IL)-6,IL-1β and tumor necrosis factor(TNF)-a were compared between the two groups.Results The total effective rate was 90.00％in the treatment group and 93.33％in the control group,and there was no significant difference in the total effective rate between the two groups(P＞0.05).The total effective rate of the two groups in the treatment of inflammatory skin lesions was 96.67％,and there was no significant difference between the two groups(P＞0.05).The total effective rate of the treatment group in the treatment of non-inflammatory skin lesions was 86.67％and 76.67％in the control group,with no statistical significance between the two groups(P＞0.05).The DLQI scores of both groups decreased significantly after treatment(P＜0.05).The TCM syndrome score in the treatment group was lower than that in the control group after treatment(P＜0.05).The levels of peripheral blood inflammatory cytokines in both groups were lower than those before treatment(P＜0.05).Conclusion Compound Yinqiaojiedu mixture combined with acupuncture clearance is effective in the treatment of moderate acne heat-toxin syndrome with little adverse reaction,and it can improve the clinical syndrome of patients,which is worthy of clinical promotion and application.
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