Research progress of antibody drugs targeting interleukin-4 receptor
Interleukin(IL)-4 is a multipotent cytokine that specifically binds to IL-4 receptor(IL-4R)on the cell surface to exert its biological effects.The expression level of IL-4R on the cell surface is relatively low under normal conditions and increases after being stimulated by hormones,stress and inflammation.At present,it has been found that IL-4/IL-4R plays an important role in the occurrence and development of atopic dermatitis,asthma,malignant tumor and other diseases.Currently,monoclonal antibody drugs targeting IL-4Rα have been used for clinical treatment,particularly for type 2 inflammation,and more than 8 therapeutic agents are in clinical research phase.This article reviewed the IL-4/IL-4R signaling pathway and related diseases,and the current status of research on therapeutic monoclonal antibody drugs targeting IL-4R and their clinical applications.
interleukin-4 receptortargeted therapyantibody drug
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