首页|吸烟、饮酒与银屑病发病及治疗结局影响的研究进展

吸烟、饮酒与银屑病发病及治疗结局影响的研究进展

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银屑病(psoriasis)是一种皮肤科常见的慢性、复发性、炎症性疾病,其确切病因尚未完全明确,遗传及环境因素是诱发或加重银屑病的重要因素,其中吸烟和饮酒是常见可控危险因素.研究显示,银屑病患者吸烟率高于一般人群,吸烟可能通过增强银屑病相关基因表达、激活银屑病发病相关信号通路等途径影响银屑病的发病和进展,从而增加银屑病的发生风险,导致银屑病患者病情加重.但吸烟是否会影响银屑病患者的治疗效果仍存争议,尚需更多研究来确认吸烟和戒烟对银屑病患者治疗效果的影响.流行病学调查显示,银屑病患者饮酒率高于一般人群.现有研究证据表明,饮酒可能通过影响银屑病相关易感基因、角质形成细胞增殖分化以及诱导免疫细胞异常活化对银屑病的发生、发展产生不利影响,同时饮酒会减弱银屑病的治疗反应,使治疗效果欠佳.但饮酒与银屑病发病和严重程度之间的关系尚无统一结论,仍需开展更多研究来探讨饮酒与银屑病之间的关联.
The influence of tobacco smoking and alcohol drinking on the occurrence,the progress and treatment outcome among psoriasis patients:the research progress
Psoriasis is a common chronic,recurrent and inflammatory disease in dermatology,and the exact etiology of psoriasis has not been completely understood.Genetic and environmental factors are important factors that induce or aggravate psoriasis,among which tobacco smoking and alcohol drinking are common controllable risk factors.Studies have shown that the tobacco smoking rate of psoriasis patients is higher than that of general population.Tobacco smoking may affect the occurrence and the progress of psoriasis by enhancing the expression of psoriasis-related genes and activating psoriasis-related signaling pathways,thus increasing the risk of psoriasis and leading to the exacerbation of the condition of psoriasis patients.However,whether tobacco smoking affects the treatment effect of psoriasis patients remains controversial,and more clinical studies are needed to confirm the impact of tobacco smoking and cessation on the treatment effect of psoriasis patients.Epidemiological investigation shows that the alcohol drinking rate of psoriasis patients is higher than that of general population.Existing research evidence suggests that alcohol drinking may have adverse effects on the occurrence and the progress of psoriasis by affecting psoriasis-related susceptibility genes,affecting the proliferation and differentiation of keratinocytes and inducing abnormal activation of immune cells.At the same time,alcohol drinking may weaken the therapeutic response of psoriasis,making the treatment less effective.However,there is no unified conclusion on the relationship between alcohol drinking and the occurrence and severity of psoriasis.So more studies are needed to explore the association between alcohol drinking and psoriasis.

tobacco smokingalcohol drinkingpsoriasisoccurrencedisease progresstreatment effect

沈范玲子、王瑞平

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上海中医药大学公共健康学院,上海 201203

上海市皮肤病医院/同济大学附属皮肤病医院临床研究与创新转化中心,上海 200443

吸烟 饮酒 银屑病 发病 疾病进展 疗效影响

上海市卫生健康委员会卫生行业临床研究专项上海市人才发展基金上海医院协会医院管理研究基金上海申康医院发展中心第二轮促进市级医院临床创新三年行动计划研究型医师创新转化能力培训项目

2022403712021SHRCFZ01X2-22117SHDC2022CRS053

2024

10.13683/j.wph.2024.01.015

世界临床药物
上海医药工业研究院

世界临床药物

CSTPCD
影响因子：0.849
ISSN：1672-9188
年,卷(期)：2024.45(1)
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