Effect of antenatal corticosteroid therapy on respiratory distress syndrome in late preterm infants
Objective To investigate the effects of antenatal corticosteroid(ACS)therapy on neonatal respiratory distress syndrome(NRDS)in late preterm infants.Methods Medical records of late preterm infants whose gestational age was 34 weeks≤age＜37 weeks,from June 2019 to June 2022 were retrospectively analyzed.According to whether the use of ACS was standardized to promote fetal lung maturation,they were divided into normative group(n=71)and non-normative group(n=79),NRDS in normative group(n=27)and NRDS in non-normative group(n=36).The effects of ACS on the incidence of NRDS,invasive ventilation time,non-invasive ventilation time,hospital stay,hospitalization costs,the use of pulmonary surfactant(PS)and complications were analyzed.Results The gestational age of normative group was higher than that of non-normative group,and the difference was statistically significant(P＜0.05).The occurrence of NRDS in the normative group was larger than that in the non-normative group(P＜0.05),and the number of PS users,invasive ventilation time and hospitalization costs were decreased(P＜0.05),and the incidence of intracranial hemorrhage was decreased(P＜0.05).Conclusion Although the standard use of ACS can't reduce the incidence of NRDS,but it can improve the condition of children,reduce the use of PS,invasive ventilation time and hospitalization costs,reduce the incidence of intraventricular hemorrhage,and do not increase the incidence of other complications.
prenatal glucocorticoidcourse of treatmentlate preterm birthneonatal respiratory distress syndromepulmonary surfactant
万方数据
维普
