Insulin plays an important role in the treatment of diabetes mellitus(DM).With the prolongation of the continuous action time of insulin analogues and the decrease of the variability of the drug effect,the long-acting basic insulin came into being.In order to seek better basic insulin that is conducive to blood glucose control and improve long-term clinical outcomes,while maximizing patient compliance and treatment continuity,eliminating barriers to initial insulin therapy,and without increasing the risk of hypoglycemia,it is imperative to develop weekly basal insulin.This article focused on the two most advanced weekly basal insulin,and reviewed their molecular structure,pharmacokinetics and published clinical study data for clinical application.
万方数据
维普
