Research progress on ceftazidime/avibactam in the clinical treatment of severe Gram-negative bacteria infection
Ceftazidime/avibactam is a combination of third-generation ceftazidime and novel non-beta-lactamase inhibitors.At present,it has been approved for the clinical treatment of severe infections with limited therapeutic drugs such as hospital-acquired pneumonia,ventilator-associated pneumonia,and complex abdominal infection,and it also has been gradually applied in the clinical treatment of complex urinary tract infection and intracranial infection,and has shown obvious advantages.This article summarized the pharmacological action,pharmacokinetics,clinical application and drug use methods of ceftazidime/avibactam,in order to provide some reference for clinical drug selection and promote rational drug use.
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