Research progress on the role and molecular mechanism of dichloroacetate in sepsis
Sepsis is a systemic inflammatory response syndrome induced by infection,and the pathophysiological changes are accompanied by metabolic disorders and abnormal inflammatory responses.However,the clinical characteristics and related molecular mechanisms of inflammation-metabolic reprogramming are still unclear.Recent studies have reported that dichloroacetate(DCA)can reverse the metabolic reprogramming secondary to sepsis,participate in cell metabolism,mitochondrial function,oxidative stress response,glucose and lipid metabolism,protein metabolism,and immune regulation,but the possible mechanism of action has not been fully clarified.To further study the effects of DCA on sepsis,this article reviewed the current application of DCA in sepsis and its possible molecular mechanisms,providing new targets,new ideas,and new methods for the prevention and treatment of sepsis.
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