首页|口服选择性雌激素受体降解剂抗乳腺癌新药艾拉司群

口服选择性雌激素受体降解剂抗乳腺癌新药艾拉司群

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选择性雌激素受体降解剂(selective estrogen receptor degrader,SERD)是雌激素受体(estrogen receptor,ER)阳性的晚期乳腺癌(breast cancer)内分泌治疗的常用药物.艾拉司群(elacestrant)是治疗晚期乳腺癌ER阳性,人表皮细胞生长因子受体(human epidermal growth factor receptor,HER)2阴性的新型口服SERD,疗效优于其他内分泌治疗,可显著改善患者中位无进展生存期,且对于ER基因α突变的乳腺癌患者有效.艾拉司群的上市将为ER阳性、HER2阴性的晚期乳腺癌患者提供更有效的治疗药物选择.
Oral selective estrogen receptor depressant,the new anti-breast cancer drug elacestrant
Selective estrogen receptor degrader(SERD)is commonly used in the endocrine therapy of estrogen receptor(ER)positive advanced breast cancer.Elacestrant is a novel oral SERD that is for the treatment of advanced breast cancer with ER-positive and human epidermal growth factor receptor(HER)2-negative.It is more effective than other endocrine therapies and can significantly improve the median progression free survival of patients,and is also effective for breast cancer patients with ER gene α mutations.The launch of elacestrant will provide a more effective treatment option for patients with ER-positive,HER2-negative advanced breast cancer.

selective estrogen receptor degraderbreast cancerelacestrantclinical efficacysafety

曾凡新、王柯厶

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重庆城市管理职业学院智慧康养学院,重庆 401331

重庆医药高等专科学校药学院,重庆 401331

选择性雌激素受体降解剂 乳腺癌 艾拉司群 临床疗效 安全性

2022年重庆城市管理职业学院高层次人才科研启动基金项目

2022KYQD03

2024

世界临床药物
上海医药工业研究院

世界临床药物

CSTPCD
影响因子:0.849
ISSN:1672-9188
年,卷(期):2024.45(3)
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