Effect of Fuzheng Yiliu Fang combined with mFOLFOX6 on intestinal flora in patients with colon cancer
Objective To investigate the effect of Fuzheng Yiliu Fang combined with mFOLFOX6 chemotherapy on the clinical benefit rate and intestinal flora of patients with colon cancer.Methods A total of 106 patients with advanced colon cancer admitted to our hospital from February 2021 to May 2023 were selected and divided into chemotherapy group(mFOLFOX6 chemotherapy)and combination group(combined with Fuzheng Yiliu Fang on the basis of chemotherapy group)according to random number table method,with 53 cases in each group.The efficacy,intestinal flora,immune indexes and incidence of adverse reactions were compared between the two groups.Results The clinical benefit rate of combination group(84.31％)was higher than that of chemotherapy group(64.00％,P＜0.05).After treatment,the number of Bifidobacterium and Lactobacillus in combination group was higher than before treatment and higher than that in chemotherapy group(P＜0.05),and the number of Escherichia coli was lower than before treatment and higher than that in chemotherapy group(P＜0.05).After treatment,the levels of CD4+and CD4+/CD8+in combination group were higher than those in chemotherapy group,and CD8+was lower than that in chemotherapy group(P＜0.05).The incidence of gastrointestinal reaction(29.41％)and myelosuppression(13.73％)in combination group were lower than those in chemotherapy group(66.00％,32.00％,P＜0.05).Conclusion Fuzheng Yiliu Fang combined with mFOLFOX6 can effectively regulate intestinal flora,significantly reduce the impact of chemotherapy on immune function,significantly reduce gastrointestinal reactions,bone marrow suppression and other adverse reactions of chemotherapy in the treatment of advanced colon cancer patients,and help to improve the clinical benefit rate.
NETL
NSTL
万方数据
