The effects of combination therapy with imrecoxib and methotrexate on serum VEGF,ESR,DKK-1 and bone metabolism in patients with ankylosing spondylitis
Objective To investigate the effects of imrecoxib combined with methotrexate(MTX)on serum vascular endothelial growth factor(VEGF),erythrocyte sedimentation rate(ESR),recombinant Dickkopf related protein 1(DKK-1),and bone metabolism in patients with ankylosing spondylitis(AS).Method A total of 113 patients with AS admitted in the rheumatology and immunology department of our hospital from June 2020 to June 2022 were selected and randomly divided into experimental group(imrecoxib+MTX,n=57)and control group(MTX,n=56)using a random number table method.The clinical efficacy,serum VEGF,ESR,DKK-1,bone metabolism indexes(bone gla protein(BGP),bone alkaline phosphatase(BALP)),and Bath AS disease activity index(BASDAI)scores,finger-ground distance,and incidence of complications between two groups were compared.Result After treatment,the total effective rate of experimental group was higher than that of control group(91.23％vs 76.79％,P＜0.05).Serum ESR and DKK-1 protein levels in two groups were lower than before,and experimental group was lower than control group(P＜0.05).Serum VEGF level in experimental group was higher than that in control group(P＜0.05).After treatment,serum BGP and BALP levels in both groups were increased,and the levels in experimental group were higher than those in control group.And C-reactive protein(CRP)level in both groups were lower than before treatment,and the experimental group was lower than that in control group(P＜0.05).BASDAI score and finger-ground distance in both groups were lower than before,and the experimental group was lower than the control group(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion The combination of imrecoxib and MTX is effective in the treatment of AS,can improve bone metabolism levels,and is worthy of clinical promotion and application.
imrecoxibmethotrexateankylosing spondylitisvascular endothelial growth factorerythrocyte sedimentation raterecombinant Dickkopf related protein 1bone metabolism
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