丹参多酚酸盐对冠状动脉粥样硬化性心脏病的临床疗效和药理机制研究进展
Research progress on clinical efficacy and pharmacological mechanism of salvianolate in treating coronary atherosclerotic heart disease
白惠敏 1冯灿 1伍锋 1樊民1
作者信息
- 1. 上海中医药大学附属岳阳中西医结合医院心内科,上海 200437
- 折叠
摘要
冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease,CAHD)临床可分为稳定型心绞痛(stable angina pectoris,SAP)、不稳定型心绞痛(unstable angina pectoris,UAP)及心肌梗死(myocardial infarction,MI),其发病机制包括内皮损伤、炎症、氧化应激、斑块破裂及血栓形成等.西药、经皮冠状动脉介入治疗及冠状动脉旁路移植术等西医疗法防治CAHD效果显著,但相关心血管不良事件发生率仍较高.丹参具有抑制炎症、降低心肌缺血损伤、抑制血小板聚集和活化、改善MI面积等作用,为治疗胸痹心痛使用率最高的中药之一,亦是CAHD治疗常用药.现针对SAP、UAP及MI发病机理,综述丹参多酚酸盐(salvianolate)对CAHD的临床疗效和药理机制研究进展,为临床提供参考.
Abstract
Coronary atherosclerotic heart disease(CAHD)can be clinically classified as stable angina pectoris(SAP),unstable angina pectoris(UAP),and myocardial infarction(MI),the pathogenesis of which includes endothelial damage,inflammation,oxidative stress,plaque rupture,and thrombosis.Western medicine,percutaneous coronary intervention and coronary artery bypass grafting are effective in the prevention and treatment of CAHD,but the incidence of cardiovascular adverse events is still high.Salvia miltiorrhiza can inhibit inflammation,reduce myocardial ischemic injury,inhibit platelet aggregation and activation,improve MI area,etc.It is one of the most commonly used Chinese medicines in the treatment of chest arthralgia and heartache,and is also a common drug in the treatment of CAHD.This paper reviewed the clinical efficacy and pharmacological mechanism of salvianolate for CAHD,based on the pathogenesis of SAP,UAP and MI,in order to provide reference for clinical practice.
关键词
丹参多酚酸盐/冠状动脉粥样硬化性心脏病/临床疗效/药理机制Key words
salvianolate/coronary atherosclerotic heart disease/clinical efficacy/pharmacological mechanism引用本文复制引用
出版年
2024
NETL
NSTL
万方数据