Research progress on the transduction and integration mechanisms of recombinant adeno-associated virus vectors
Recombinant adeno-associated virus vectors are widely used as delivery vectors for gene therapy products due to their low integration rate and low pathogenicity.But,they can still be integrated in the host genome,resulting in potential genotoxicity risks.So,it is necessary to conduct in-depth research on the transduction process and genome integration mechanism of recombinant adeno-associated virus vectors,in order to establish an appropriate and efficient genotoxicity evaluation method.This paper introduced the biological characteristics of recombinant adeno-associated virus vectors,reviewed the transduction process,possible integration mechanisms,integration site preferences and potential genotoxicity risks,and prospected the genotoxicity evaluation methods of recombinant adeno-associated virus vectors,to provide a reference for further evaluation of the genotoxicity risk of recombinant adeno-associated virus vectors.
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