糖皮质激素诱发骨质疏松研究进展
Research progress on glucocorticoid induced osteoporosis
罗文 1陈静1
作者信息
- 1. 绵阳市第三人民医院,四川省精神卫生中心临床药学科,四川绵阳 621000
- 折叠
摘要
糖皮质激素(glucocorticoid,GC)被广泛用于炎症、免疫系统疾病的治疗,但长期、高剂量使用可引发多种药物相关不良反应,其中包括GC诱发的骨质疏松(glucocorticoid induced osteoporosis,GIO).GC过量可对骨细胞产生有害影响,导致骨形成和骨吸收受损,故所有长期使用GC者需定期接受骨折风险评估.现总结GIO发病机制、临床表现、骨折风险和治疗策略,为临床提供一定参考.
Abstract
Glucocorticoid(GC)is widely used in the treatment of inflammation and immune system diseases,but long-term and high-dose use can cause various drug-related adverse reactions,including GC induced osteoporosis(GIO).Excessive GC can have harmful effects on bone cells,leading to impaired bone formation and resorption.Therefore,all long-term users of GC need to undergo regular fracture risk assessments.The article discussed the pathogenesis,clinical manifestations,fracture risk,and treatment strategies of GIO,to provide some reference for clinical practice.
关键词
糖皮质激素/骨质疏松/成骨细胞/破骨细胞/骨细胞Key words
glucocorticoid/osteoporosis/osteoblast/osteoclast/bone cell引用本文复制引用
出版年
2024
NETL
NSTL
万方数据