首页|糖皮质激素诱发骨质疏松研究进展

糖皮质激素诱发骨质疏松研究进展

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糖皮质激素(glucocorticoid,GC)被广泛用于炎症、免疫系统疾病的治疗,但长期、高剂量使用可引发多种药物相关不良反应,其中包括GC诱发的骨质疏松(glucocorticoid induced osteoporosis,GIO).GC过量可对骨细胞产生有害影响,导致骨形成和骨吸收受损,故所有长期使用GC者需定期接受骨折风险评估.现总结GIO发病机制、临床表现、骨折风险和治疗策略,为临床提供一定参考.
Research progress on glucocorticoid induced osteoporosis
Glucocorticoid(GC)is widely used in the treatment of inflammation and immune system diseases,but long-term and high-dose use can cause various drug-related adverse reactions,including GC induced osteoporosis(GIO).Excessive GC can have harmful effects on bone cells,leading to impaired bone formation and resorption.Therefore,all long-term users of GC need to undergo regular fracture risk assessments.The article discussed the pathogenesis,clinical manifestations,fracture risk,and treatment strategies of GIO,to provide some reference for clinical practice.

glucocorticoidosteoporosisosteoblastosteoclastbone cell

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绵阳市第三人民医院,四川省精神卫生中心临床药学科,四川绵阳 621000

糖皮质激素 骨质疏松 成骨细胞 破骨细胞 骨细胞

2024

世界临床药物
上海医药工业研究院

世界临床药物

CSTPCD
影响因子:0.849
ISSN:1672-9188
年,卷(期):2024.45(5)
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