Influences of fire needling combined with Huoxue Huayu decoction on the changes in nail fold microcirculation and the level of serum vWF of patients with psoriasis vulgaris with blood stasis syndrome
Objective To investigate the influences of fire needling combined with Huoxue Huayu decoction on the changes in nail fold microcirculation and the level of serum von Willebrand factor(vWF)of patients with psoriasis vulgaris(blood stasis syndrome).Methods 120 patients with psoriasis vulgaris who were treated in our hospital from October 2021 to August 2022 were selected as the research objects.The patients were grouped into fire-needling group,decoction group,and combined group by random number table method,with 40 cases per group.The patients in the fire-needling group were treated with fire-needling on the target skin lesion area,Geshu,Ganshu and Shenshu points,and the patients in the decoction group were treated with self-made Huoxue Huayu decoction orally,and the patients in the combined group were treated with fire needling combined with Huoxue Huayu decoction.The morphological changes of nail fold microcirculation and serum vWF,antithrombin Ⅲ activity(AT-ⅢA),and plasminogen activator inhibitor-1(PAI-1)levels were compared among the three groups.Results After treatment,compared with the fire-needling group and the decoction group,the psoriasis area and severity index(PASI),loop shape,fluid state,and peri-loop state,serum PAI-1 and vWF levels in the combined group were lower(P＜0.05),and the serum AT-ⅢA level was higher(P＜0.05).At 8 and 12 weeks after treatment,the PASI improvement rate of 75％in the combined group was higher than that of fire-needling group and decoction group(P＜0.05).Conclusion Fire needling combined with Huoxue Huayu Decoction in the treatment of psoriasis vulgaris can improve the curative effect,reduce skin damage,and improve the morphological changes of nail fold microcirculation and blood hypercoagulability.
fire needlingHuoxue Huayu decoctionpsoriasiscurative effectnail fold microcirculationvon Willebrand factor
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