The mechanism of immune system action in non-alcoholic fatty liver disease and the prospects for stem cell therapy
Nonalcoholic fatty liver disease(NAFLD),as a widespread chronic hepatic disease,is caused by the accumulation of hepatocellular triglyceride,instigating immunological engagement and accompanied by histopathological alterations.NAFLD's a progressive ailment,and the inflammatory response is the driving force in the progression of NAFLD,with various triggers involving metabolic damage often leading to the activation of different immunocytes.The specific drug for NAFLD remains deficient.Stem cell-derived exosomes,representing an innovative therapeutic modality with minimized immunogenicity,are used to suppress the immune reactions in tissues.This article aimed to explore the pathogenesis of NAFLD and the importance of liver in human immunity,discuss the role of different immunocytes in the pathogenesis and progression of NAFLD,deeply understand the pathogenesis of immunocytes involved in NAFLD,summarize the current immunotherapy,and to provide theoretical support for the design of new immunotherapy.
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