Advances in the mechanism of chemotherapy-induced peripheral neurotoxicity based on mitochondrial damage
Chemotherapeutic drugs are one of the common methods for clinical treatment of tumor diseases.However,chemotherapy-induced peripheral neurotoxicity(CIPN)has become a major factor affecting patients'daily life and work.Mitochondrial damage is one of the main causes of the formation and development of CIPN.When mitochondria are damaged,mitochondrial-derived damage-associated molecular patterns(mtDAMPs)are released into the extracellular environment,which can induce inflammatory responses.Therefore,it is of great significance to explore the mechanism of mtDAMPs in CIPN.However,although there is a large amount of data describing the widespread effects of mtDAMPs on CIPN,the exact mechanism remains unelucidated.Therefore,the mechanism of mtDAMPs induced CIPN and its potential therapeutic agents were reviewed in this paper to provide reference for clinical and non-clinical studies.
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