Progress in the study of the role and mechanism of artemisinin and its derivatives in skin diseases
Artemisinin and its derivatives,including artemether,dihydroartemisinin,artesunate,are natural products extracted from the traditional Chinese plant Artemisia annua L..Artemisinin and its derivatives have anti-parasitic,anti-viral,antibacterial,antifungal,anti-inflammatory,anticancer,immunomodulatory and other effects,and play an important role in inflammatory skin diseases,photoaging and skin tumors.The main mechanisms of action in the treatment of skin-related diseases include regulating immune cell function,reducing the level of inflammatory factors,regulating cell signaling pathways,and inhibiting the proliferation of tumor cells.This paper described the effects of artemisinin and its derivatives on the above mentioned skin diseases in terms of therapeutic efficacy and mechanism of action,and summarized the relevant action targets and pathways,so as to provide reference for further study of its application.
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