The efficacy of sequential administration of sacubitril valsartan and enalapril in the treatment of chronic heart failure
Objective To investigate the efficacy of sequential administration of sacubitril valsartan and enalapril in the treatment of chronic heart failure(CHF).Methods A total of 112 CHF patients were randomly divided into the observation group(sequential administration of sacubitril valsartan and enalapril)and the control group(enalapril),with 56 cases in each group.The efficacy,cardiac function,myocardial enzyme spectrum index,serum myeloid differentiation factor(MyD)88,microRNA(miR)-30a,miR-101a,and quality of life were compared between the two groups before and 6 months after treatment.Results After treatment,the total effective rate in the observation group was higher than that in the control group(96.43％vs 83.93％,P＜0.05).Left ventricular end-diastolic diameter,left ventricular end-systolic diameter,creatine kinase,creatine kinase isoenzyme,hydroxybutyrate dehydrogenase,cardiac troponin,N-terminal brain natriuretic peptide,MyD88,miR-30a and score of Minnesota Living with HF Questionnaire were lower than before treatment in the both groups,and the observation group was lower than the control group(P＜0.05).Left ventricular ejection fraction,6 minutes walking distance and miR-101a were higher than before treatment in both groups,and the observation group was higher than control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(12.50％vs 8.93％,P＞0.05).Conclusion Sequential administration of sacubitril valsartan and enalapril is safe and effective in the treatment of CHF,promoting the improvement of cardiac function and quality of life of patients.
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