Effect of roxadustat on hemoglobin compliance rate and serum folate level in renal anemia patients with low responsiveness to erythropoietic stimulant receiving maintenance hemodialysis
Objective To explore the effect of roxadustat on renal anemia(RA)patients with low responsiveness to erythropoietic stimulant(ESA)receiving maintenance hemodialysis(MHD),and its effects on serum hemoglobin(Hb)compliance rate and folic acid(FA)level.Methods A total of 100 RA patients with low responsiveness to ESA receiving MHD in the department of nephrology in our hospital were selected and randomly divided into recombinant human erythropoietin(rhEPO)group and roxadustat group,50 cases in each group.The two groups were treated continuously for 12 weeks,and the Hb compliance rate and serum FA level were compared between the two groups after treatment.Results At 4 and 12 weeks of treatment,the Hb compliance rate in roxadustat group was higher than that in rhEPO group(P＜0.05).After treatment,serum Hb,FA,hematocrit,erythrocyte count and vitamin B12 levels in roxadustat group were higher than those in rhEPO group(P＜0.05),serum ferritin,transferrin saturation and serum iron level in roxadustat group were lower than those in rhEPO group(P＜0.05).Conclusion Roxadustat has significant efficacy in RA patients with low responsiveness to ESA receiving MHD,which can effectively improve anemia status,increase Hb compliance rate and serum FA level,improve iron metabolism,and has good safety.
roxadustatmaintenance hemodialysisrenal anemia with low responsiveness to erythropoietic stimulanthemoglobin compliance rateserum folic acid
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