Effect of combination of Qiyu prescription and vitamin D in the treatment of Hashimoto's thyroiditis of Qi deficiency and liver depression syndrome
Objective To observe the effect of combination of Qiyu prescription and vitamin D on Hashimoto's thyroiditis(HT)of Qi deficiency and liver depression syndrome.Methods A total of 113 HT patients with Qi deficiency and liver depression syndrome in department of endocrinology of our hospital from March to December 2023 were included and randomly divided into traditional Chinese medicine(TCM)group(n=38,basic treatment+Qiyu prescription),TCM+vitamin D group(n=38,basic treatment+Qiyu prescription+alfacalcidol)and control group(n=37,basic treatment).All patients were treated for 12 weeks.Thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb),thyroid-stimulating hormone(TSH)levels and TCM syndrome scores of three groups were observed before and after treatment.Results The clinical effective rates of TCM group and TCM+vitamin D group were 78.95％and 84.21％,which were higher than control group(40.54％)(P＜0.05).The titers of thyroid autoantibody in TCM group and TCM+vitamin D group were lower than before treatment(P＜0.05),and the change rates of antibody were better than that in control group,and the change rates of TPOAb in TCM+vitamin D group were better than that in TCM group(P＜0.05).TCM syndrome scores in TCM group and TCM+vitamin D group were lower than before treatment(P＜0.05),and better than control group(P＜0.05).Conclusion Combination of Qiyu prescription and vitamin D has a better effect on HT patients with Qi deficiency and liver depression syndrome,and can reduce serum TPOAb and TgAb levels,which is more effective on TPOAb compared to the use of TCM alone.
Qiyu prescriptionvitamin DQi deficiency and liver depression syndromeHashimoto's thyroiditis
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