Effects of Molian Qubai decoction combined with 308 nm excimer laser on white spot area and serum total complement activity in patients with vitiligo of kidney deficiency and blood stasis type
Objective To observe the clinical efficacy of Molian Qubai decoction combined with 308 nm excimer laser in treating vitiligo of kidney deficiency and blood stasis type.Methods A total of 86 patients with vitiligo of kidney deficiency and blood stasis type were divided into control group and study group by simple ranking random scheme and the random number table method,with 43 cases in each group.The control group received 308 nm excimer laser,and the study group received Molian Qubai decoction combined with 308 nm excimer laser.The efficacy,white spot area,white spot resolution time,immunoglobulin(Ig)G,IgM,IgA,serum complement hemolytic activity(CH50),T lymphocyte subpopulations,and adverse reactions in the two groups were compared.Results The total effective rate of the study group was higher than that of the control group(90.70％vs 72.09％,P＜0.05).After treatment,the vitiligo area score index,and the levels of IgG,IgM,and IgA in both groups were lower than before treatment(P＜0.05),and the study group were lower than the control group(P＜0.05).The time for white spot regression in the study group was earlier than that in the control group(P＜0.05).After treatment,the levels of CH50,CD3+,CD4+,CD4+/CD8+in both groups were higher than before treatment(P＜0.05),and the study group was higher than the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Molian Qubai decoction and 308 nm excimer laser can enhance the immune function of patients with vitiligo of kidney deficiency and blood stasis type,reduce the area of white spots,accelerate the resolution of white spots,improve the therapeutic effect,and do not increase adverse reactions.
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