Effects of tonifying deficiency and nourishing stomach decoction combined with omeprazole on chronic atrophic gastritis and on epidermal growth factor,motilin and soluble interleukin-2 receptor
Objective To investigate the effect of tonifying deficiency and nourishing stomach decoction combined with omeprazole(OME)in the treatment of chronic atrophic gastritis(CAG)and its effect on epidermal growth factor(EGF),motilin(MTL)and soluble interleukin-2 receptor(sIL-2R)levels.Methods A total of 109 patients with CAG in our hospital from January 2021 to January 2023 were selected and divided into the experimental group(OME+tonifying deficiency and nourishing stomach decoction,n=55)and the control group(OME,n=54)by random number table method.The clinical efficacy,EGF,MTL,sIL-2R,gastrin(GAS),pepsinogen(PG),traditional Chinese medicine symptom score and occurrence of adverse reactions were compared between the two groups after corresponding treatment.Results After treatment,the total effective rate of experimental group was higher than that of control group(87.27％vs 70.37％,P＜0.05).The levels of EGF,GAS and PG in both groups were higher than before(P＜0.05),and the levels in experimental group were more significantly higher than those in control group(P＜0.05).The levels of sIL-2R and MTL in both groups were lower than before(P＜0.05),and the levels in experimental group were more significantly lower than those in control group(P＜0.05).The scores of epigastric pain,belching,distension and noisy pantothenic acid in both groups were significantly decreased(P＜0.05),and the scores in experimental group were more significantly decreased than those in control group(P＜0.05).During treatment,the adverse reactions mainly included loss of appetite,lethargy,nausea and vomiting,but there was no significant difference in incidence between the two groups(P＞0.05).Conclusion Tonifying deficiency and nourishing stomach decoction combined with OME has better efficacy in CAG,which can effectively improve EGF level,reduce MTL and sIL-2R levels,improve clinical symptoms and have good safety.
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