Influencing factors of treatment efficacy for patients with psoriasis vulgaris in Shanghai
Objective To incestigate the current status,efficacy and influencing factors of drug therapy for psoriasis patients in Shanghai.Method An epidemiological observational study was conducted which enrolled 560 psoriasis patients in two hospitals from January 2022 to December 2022.Information on smoking,alcohol consumption,chronic comorbidities,and clinical evaluation of skin lesions were collected based on a questionnaire survey.Follow-up was conducted at 4 and 8 weeks after treatment to evaluate the efficacy and influencing factors of drug therapy.Results The average age of all patients was(48.4±15.1)years old.The rates of smoking,alcohol consumption and chronic comorbidities were 43.8％,25.4％,and 53.9％,respectively.The proportion of patients receiving acitretin,methotrexate,narrow band ultraviolet B(NB-UVB)phototherapy,benvitimod and biological agent therapy were 13.2％,19.3％,16.8％,4.8％and 45.9％,respectively.After deducting other influencing factors,patients receiving NB-UVB phototherapy[OR=2.29,95％confidence interval(CI):1.01～5.18],benvitimod(OR=4.24,95％CI:1.37～13.15),and biological agent therapy(OR=12.55,95％CI:5.93～26.57)for 8-week had a higher PASI75 achievement rate for psoriasis.Conclusion Risk factors such as smoking,alcohol consumption and chronic comorbidities are closely related to the efficacy of psoriasis.It is recommended to strengthen the promote a healthy lifestyle in psoriasis patients,quit smoking and limit alcohol consumption,reduce the incidence of psoriasis comorbidities,which is important for the treatment and prognosis of psoriasis.
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