血清白蛋白联合SNAPPE-Ⅱ在早产儿感染病情及预后中的预测价值
Predictive value of serum albumin combined with SNAPPE-Ⅱ in infection and prognosis of premature infants
葛娟 1汪晶晶 1王红群1
作者信息
- 1. 华东师范大学附属芜湖医院,芜湖市第二人民医院儿科,安徽芜湖 241000
- 折叠
摘要
目的 探讨血清白蛋白(albumin,ALB)水平、新生儿急性生理评分(score for neonatal acute physiology with perinatal extension,SNAPPE)-Ⅱ对早产儿感染病情及预后的预测价值.方法 回顾性选择感染早产儿为感染组(n=46)、同期无感染者为对照组(n=36).比较并分析ALB、SNAPPE-Ⅱ及二者联合对预测两组早产儿感染的价值.结果 两组住院时间、吸氧时间、机械通气时间、无创正压通气时间以及静脉营养时间差异显著(P＜0.05).两组ALB、SNAPPE-Ⅱ差异均有统计学意义(P＜0.05).多因素非条件logistic分析结果显示,住院时间、吸氧时间、机械通气时间、无创正压通气时间、静脉营养时间及SNAPPE-Ⅱ是早产儿感染发生的独立危险因素(P＜0.05),ALB水平是早产儿感染发生的独立保护因素(P＜0.05).SNAPPE-Ⅱ对早产儿感染进行受试者工作特征曲线分析,ALB、SNAPPE-Ⅱ及二者联合诊断早产儿感染曲下面积分别为0.761、0.738、0.893,二者联合效能最高.结论 血清ALB、SNAPPE-Ⅱ对早产儿感染预后诊断均具有较佳价值,且二者联合效果更好,可帮助指导合理、及时进行抗菌药物治疗,改善预后.
Abstract
Objective To investigate the predictive value of serum albumin(ALB)level and score for neonatal acute physiology with perinatal extension(SNAPPE)-Ⅱ in infection and prognosis of premature infants.Methods The infected premature infants were selected as the infected group(n=46)and the control group without infected infants(n=36).The value of ALB,SNAPPE-Ⅱ and their combination in predicting the infection of preterm infants in two groups were compared and analyzed.Results There were significant differences in hospitalization time,oxygen inhalation time,mechanical ventilation time,non-invasive positive pressure ventilation time,and intravenous nutrition time between the two groups(P＜0.05).The differences in ALB and SNAPPE-Ⅱ between the two groups were statistically significant(P＜0.05).The results of multivariate unconditional logistic analysis showed that hospitalization time,oxygen inhalation time,mechanical ventilation time,non-invasive positive pressure ventilation time,intravenous nutrition time,and SNAPPE-Ⅱ were independent risk factors for premature infant infection(P＜0.05),and ALB level was an independent protective factor for premature infant infection(P＜0.05).receiver operating characteristic curve analysis of SNAPPE-Ⅱfor premature infant infection showed that the area under the curve of ALB,SNAPPE-Ⅱ,and their combination for diagnosing premature infant infection were 0.761,0.738,and 0.893,respectively,the combination of the two showed the highest efficacy.Conclusion Serum ALB and SNAPPE-Ⅱ have better value in prognosis diagnosis of infection in premature infants,and their combined effect is better,which can guide rational and timely antimicrobial therapy and improve prognosis.
关键词
血清白蛋白/新生儿急性生理评分-Ⅱ/早产儿感染/预测价值Key words
serum albumin/score for neonatal acute physiology with perinatal extension-Ⅱ/infection of premature infant/predictive value引用本文复制引用
基金项目
芜湖市科技计划重点研发项目(2020ms3-12)
出版年
2024
NETL
NSTL
万方数据