Research progress and clinical application prospect of oxygen sensing mechanism in breast cancer
Breast cancer is one of the common malignant tumors,which seriously threatens women's health.As a kind of solid tumor,breast cancer can produce hypoxic areas due to the abnormal structure and function of the microvascular system.Hypoxia is generally positively associated with a more aggressive phenotype,increased risk of metastasis,and resistance to tumor therapy.In this paper,the oxygen sensing mechanisms mediated by different types of-ketoglutarate-dependent dioxygenase in breast cancer and their clinical application prospects were summarized,in order to deepen the understanding of oxygen sensing mechanisms and functions in breast cancer.
breast cancerα-ketoglutaric acid dependent dioxygenaseoxygen-sensing pathwayclinical application prospect
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