Research progress of 5-methylcytosine methylation on tumor regulation
5-methylcytosine(m5C)methylation is an important epigenetic regulation of RNA post-transcriptional modification.Evidence suggests that m5C methylation can regulate RNA stability,translation,transcription,nuclear output and cleavage,thereby mediating cell proliferation,differentiation,apoptosis,stress response and other biological functions.The m5C methylation modification process is catalyzed by m5C methyltransferase,m5C demethyltransferase and m5C methylbinding enzyme.Abnormal expression of multiple methylation modifying enzymes has been found in various cancers and is used to predict patients'outcomes.This paper reviewed the regulatory effects of m5C methylation modification on tumors,and discussed the prospect of related research.
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