The effect of Qingfei granules on serum inflammatory markers and mucoprotein 5AC in sputum of patients with chronic obstructive pulmonary disease accompanied by respiratory failure
Objective To observe the effect of Qingfei granules on serum inflammatory markers and mucprotein(MUC)5AC in patients with chronic obstructive pulmonary disease(COPD)accompanied by respiratory failure.Methods SPSS 26.0 software was used to generate random numbers,and the patients were randomly divided into a treatment group and a control group according to the order of their visits.All patients received routine treatment for 14 days,and at the same time,the treatment group took oral Qingfei granules and the control group took a placebo.Total clinical effective rate,patient symptoms,traditional Chinese medicine(TCM)syndrome scores,arterial oxygen pressure(PaO2),arterial carbon dioxide pressure(PaCO2),serum D-dimer,C-reactive protein(CRP),interleukin(IL)-6,MUC5AC levels,and adverse reactions were observed.Results Sixty-four cases with COPD accompanied by respiratory failure admitted to the Department of Respiratory,Shanghai Municipal Hospital from December 2021 to September 2023 were selected.Before treatment,there was no significant difference in single symptom score,TCM syndrome scores,PaO2.PaCO2,the levels of serum D-dimer,CRP,IL-6,and MUC5AC between the two groups(P＞0.05).After treatment,the total effective rate of the treatment group was higher than that of the control group,with statistical difference(P＜0.05).There was a significant difference in TCM syndrome scores between the two groups(P＜0.05).The PaO2 in both groups increased significantly after treatment(P＜0.05),but there was no significant difference between the two groups after treatment(P＞0.05).The PaCO2 in both groups decreased significantly after treatment(P＜0.05),but there was no significant difference between the two groups after treatment(P＞0.05).The levels of CRP,IL-6,and MUC5AC in both groups decreased significantly compared to before treatment(P＜0.05),and the levels of IL-6,and MUC5AC in the treatment group were significantly decreased compared to the control group(P＜0.05).There was no serious adverse reactions in both groups.Conclusion Qingfei granules can effectively improve expectoration difficulties,reduce airway mucus hypersecretion,suppress inflammatory reactions,and improve respiratory function in patients with COPD accompanied by respiratory failure.
chronic obstructive pulmonary disease with respiratory failureQingfei granulesserum inflammatory factorsmucoprotein5AC
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