Effect of recombinant human brain natriuretic peptide combined with ultrafiltration on biomarkers in acute stage of senile heart failure
Objective To investigate the effects of recombinant human brain natriuretic peptide(rhBNP)combined with intravenous blood ultrafiltration on N-terminal pro brain natriuretic peptide(NT-proBNP),glucose-regulatory protein(GRP)78,pentraxin(PTX)3 and growth differentiation factor(GDF)-15 in elderly patients with acute decompensation of chronic heart failure.Methods A total of 130 elderly patients with acute decompensation of chronic heart failure in our hospital from January 2021 to November 2023 were selected and randomly divided into experimental group and control group according to random number table,with 65 cases in each group.The experimental group received conventional therapy+venous blood ultrafiltration+rhBNP,and the control group received conventional therapy+venous blood ultrafiltration.The clinical efficacy,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and serum level of NT-proBNP],the serum levels of GRP78,PTX3,GDF-15 and the incidence of adverse reactions were statistically analyzed in the two groups.Results The total effective rate of experimental group was higher than that of control group(96.92％vs 81.54％,x2=4.029,P=0.046).After treatment,LVEF in both groups was higher than before treatment(P＜0.01),and the experimental group was higher than the control group(P＜0.01),while LVEDD,LVESD and the serum level of NT-proBNP were lower than before treatment(P＜0.01),and the experimental group was lower than the control group(P＜0.01).After treatment,the serum levels of GRP78,PTX3 and GDF-15 in both groups were decreased compared with before treatment(P＜0.05 or P＜0.01),and the experimental group was lower than the control group(P＜0.05 or P＜0.01).There was no significant difference in the incidence of adverse reactions between the two groups(26.15％vs 16.92％,x2=0.369,P=0.642).Conclusion rhBNP combined with blood ultrafiltration can alleviate the inflammatory damage and stress damage of myocardium in elderly patients with acute decompensation of chronic heart failure,enhance the pumping capacity of the heart,reduce the volume load of the heart,and improve the overall cardiac function.
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