Mechanism of cardiovascular aging:impaired macroautophagy function and epigenetic changes
The cardiovascular system operates under continuous mechanical and metabolic pressure,and as age increases,the risk of functional impairment at the molecular,cellular,and organ levels gradually increases.Especially with impaired macroautophagy function and epigenetic changes,including DNA methylation,histone modifications,and non-coding RNA.These cardiovascular aging mechanisms are closely intertwined,and the strengthening or weakening of individual mechanisms can affect other mechanisms.Understanding these cardiovascular aging mechanisms is expected to provide new ideas and directions for the diagnosis of cardiovascular diseases and the development of new drugs in the future.
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