Effect of meropenem combined with probiotics in the treatment of patients with cirrhosis complicated with spontaneous bacterial peritonitis
Objective To explore the effects of meropenem combined with probiotics on inflammatory response and intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis(SBP)caused by liver cirrhosis.Methods A total of 102 patients with cirrhosis complicated with SBP who were treated in Jing-an district central hospital from January 2021 to March 2023 were selected as the study objects,and were divided into 52 cases in the control group(meropenem treatment)and 50 cases in the study group(meropenem combined with bifidobacterium triactive enteric capsule treatment).The curative effect,inflammatory factor levels,intestinal mucosal barrier function,and adverse reactions before and after the treatment were compared between the two groups.Results The total effective rate of the study group(94.00％)was significantly higher than that of the control group(78.85％)(P＜0.05).After treatment,the levels of inflammatory factors,diamine oxidase,D-lactic acid and the ratio of urinary lactulose excretion rate to mannitol excretion rate were decreased in two groups(P＜0.05),and the decrease was more significant in the study group than in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Probiotics combined with meropenem can effectively improve the clinical efficacy of cirrhosis complicated with SBP,inhibit the secretion of inflammatory factors,improve the intestinal mucosal barrier function of patients,and have a high safety.
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