Effect of Yiqi Yangyin Qufeng recipe on inflammatory factors and oxidative stress in patients with type 2 diabetes nephropathy
Objective To observe the effects of Yiqi Yangyin Qufeng recipe on inflammatory factors and oxidative stress in patients with type 2 diabetic nephropathy(DN).Methods A total of 60 patients with type 2 DN admitted to nephrology departments of outpatient and inpatient of our hospital from January 2022 to June 2023 were included and randomly divided into treatment group and control group,with 30 cases in each group.All patients were given lifestyle guidance to control blood glucose,blood lipids,etc.The treatment group was also given Yiqi Yangyin Qufeng recipe,and the control group was also given valsartan.The treatment course was 12 weeks.Traditional Chinese medicine(TCM)syndrome score,clinical efficacy,serum creatinine(Scr),urinary albumin/creatinine(UACR),peripheral blood mononuclear cell nuclear factor(NF)-κBP65,urinary monocyte chemotactic stimulating factor(UMCP)-1,interleukin(IL)-1,IL-6,tumor necrosis factor(TNF)-α,highly sensitive C-reactive protein(hs-CRP),superoxide dismutase(SOD),and serum malondialdehyde(MDA)levels were observed and compared between the two groups before and after treatment.Results The total effective rate of the treatment group was higher than that of the control group(86.67％vs 63.33％,P＜0.05).The treatment group was superior to the control group in improving the levels of TCM syndrome score,UACR,NF-κBP65,TNF-α,IL-1,IL-6,SOD,MDA and UMCP-1(P＜0.05),and there were no significant differences in the levels of Scr and hs-CRP between the two groups(P＞0.05).Correlation analysis showed that NF-κBp65 was positively correlated with UMCP-1(r=0.562 1,P＜0.05).Conclusion Yiqi Yangyin Qufeng recipe can reduce the expression level of inflammatory factors and inhibit oxidative stress in type 2 DN patients,which can be regarded as one of the effective drugs for type 2 DN.
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