罗沙司他辅助促红细胞生成素对肾性贫血患者疗效及对转铁蛋白、转铁蛋白饱和度的影响
Effect of roxallistat assisted erythropoietin on renal anemia patients and its effect on transferrin and transferrin saturation
杨永彪 1丁广贵 1何猛 1钟颉 1吴雪平2
作者信息
- 1. 明光市人民医院肾病医学科,安徽滁州 239400
- 2. 蚌埠医学院第一附属医院肾病科,安徽蚌埠 233004
- 折叠
摘要
目的 探讨罗沙司他辅助促红细胞生成素(erythropoietin,EPO)对肾性贫血(renal anemia,RA)患者的疗效及对转铁蛋白(transferrin,TRF)、TRF 饱和度(transferrin saturation,TSAT)等的影响.方法 选择 2021年1月至 2023年12月明光市人民医院肾病医学科接受治疗的RA患者179例,以随机数表法分为试验组(n=90,EPO+罗沙司他)和对照组(n=89,EPO),两组均治疗12个月.比较两组临床疗效、TRF、TSAT、贫血指标[红细胞(red blood cell,RBC)、血红蛋白(hemoglobin,Hb)、血清铁蛋白(serum ferritin,SF)]水平及不良反应发生情况.结果 治疗后,试验组临床有效率高于对照组(91.11％vs 79.78％,P＜0.05).两组TRF、TSAT、RBC、Hb、SF水平较前均升高(P＜0.05),且试验组高于对照组(P＜0.05).试验组及对照组不良反应发生率分别为6.67％、10.11％,无明显差异(P＞0.05).结论 罗沙司他辅助EPO治疗RA效果较佳,改善TRF、TSAT水平及贫血情况良好.
Abstract
Objective To investigate the effect of roxallistat assisted erythropoietin(EPO)on patients with renal anemia(RA)and its effect on transferrin(TRF)and TRF saturation(TSAT)levels.Methods A total of 179 RA patients treated in the department of nephrology,Mingguang people's hospital from January 2021 to December 2023 were selected and divided into experimental group(n=90,EPO+roxallistat)and control group(n=89,EPO)by random number table method.Both groups were treated for 12 months.The clinical efficacy,TRF,TSAT,serum indexes of anemia[red blood cell(RBC),hemoglobin(Hb),serum ferritin(SF)]and the incidence of adverse reactions were compared between the two groups.Results After treatment,the clinical effective rate of experimental group was higher than that of control group(91.11％vs 79.78％,P＜0.05).The levels of TRF,TSAT,RBC,Hb and SF in both groups were higher than before(P＜0.05),and the experimental group was higher than the control group(P＜0.05).The incidence of adverse reactions in experimental group and control group was 6.67％and 10.11％,respectively,with no significant difference(P＞0.05).Conclusion Roxallistat assisted EPO in the treatment of RA is effective,and can improve the level of TRF,TSAT and anemia.
关键词
罗沙司他/促红细胞生成素/肾性贫血/转铁蛋白/转铁蛋白饱和度Key words
roxallistat/erythropoietin/renal anemia/transferrin/transferrin saturation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据