首页|新生儿重症监护高危儿脑损伤的多因素风险评估与分析

新生儿重症监护高危儿脑损伤的多因素风险评估与分析

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目的 探讨新生儿重症监护病房(neonatal intensive care unit,NICU)高危儿脑损伤的危险因素.方法 选择芜湖市第二人民医院2019年3月至2023年3月收治的NICU高危儿655例作为研究对象,根据是否发生脑损伤将其分为脑损伤组(n=131)和无脑损伤组(n=524).监测并记录两组基线资料、胎儿宫内窘迫(fetal distress in uterus,FDIU)、分娩方式、机械通气(mechanical ventilation,MV)、辅助生育技术、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、25羟基维生素D[25 hydroxyvitamin D,25(OH)D]等.以单因素分析、logistic回归分析方法分析影响NICU高危儿脑损伤的危险因素.结果 较无脑损伤组,脑损伤组低体质量例数、FDIU例数、MV例数、产前高危因素、母亲感染、BDNF和25(OH)D水平均较高(P<0.05).Logistic回归分析示,低体质量、FDIU、MV、产前高危因素、母亲感染、BDNF、25(OH)D是影响NICU高危儿脑损伤的危险因素(P<0.05).结论 低体质量、FDIU、MV、产前高危因素、母亲感染、BDNF、25(OH)D是影响NICU高危儿脑损伤的危险因素.在考虑上述因素基础上,在临床中可有针对性地防控干预,帮助降低脑损伤发生风险.
Multivariate risk assessment and analysis of brain injury in high-risk infants in neonatal intensive care unit
Objective To investigate the risk factors of brain injury in high-risk infants in neonatal intensive care unit(NICU).Methods A total of 655 high-risk NICU infants admitted to the second people's hospital ofWuhu from March 2019 to March 2023 were selected as the study objects,which were divided into brain injury group(n=131)and no brain injury group(n=524)according to whether brain injury occurred.Baseline data,fetal distress in uterus(FDIU),mode of delivery,mechanical ventilation(MV),assisted fertility technologies,brain-derived neurotrophic factor(BDNF),25 hydroxyvitamin D[25(OH)D]were monitored and recorded.Univariate analysis and logistic regression analysis were used to analyze the risk factors of brain injury in NICU high-risk infants.Results Compared with no brain injury group,the number of low body mass cases,FDIU cases,MV cases,prenatal risk factors,maternal infection,BDNF and 25(OH)D levels in brain injury group were higher(P<0.05).Logistic regression analysis showed that low body weight,FDIU,MV,prenatal risk factors,maternal infection,BDNF,25(OH)D were risk factors for brain injury in NICU high-risk infants(P<0.05).Conclusion Low body mass,FDIU,MV,prenatal risk factors,maternal infection,BDNF,25(OH)D were risk factors for brain injury in NICU high-risk infants.On the basis of considering the above factors,targeted interventions can be taken in clinic to help reduce the risk of brain injury.

neonatal intensive care unithigh-risk infantbrain injuryrisk factor

黄道丹、何国华、朱敏、赵晓科、阚清、孙子家

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南京医科大学附属儿童医院康复医学科,江苏南京 210008

芜湖市第二人民医院儿科,安徽芜湖 241000

南京医科大学附属儿童医院新生儿科,江苏南京 210008

新生儿重症监护病房 高危儿 脑损伤 危险因素

国家自然科学基金江苏省科教强卫青年人才江苏省妇幼保健协会科研项目南京市卫健委一般性课题

81401864QNRC2016089FYX201907YKK19108

2024

世界临床药物
上海医药工业研究院

世界临床药物

CSTPCD
影响因子:0.849
ISSN:1672-9188
年,卷(期):2024.45(9)
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