非酒精性脂肪肝病中上皮-间充质转化过程的研究现状
Research status of epithelial-mesenchymal transition in non-alcoholic fatty liver disease
白鑫 1刘珉宇1
作者信息
- 1. 中国医药工业研究总院创新药物与制药工艺国家重点实验室,上海 200437;上海市生物物质成药性评价技术服务平台,上海 200437
- 折叠
摘要
非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)是全球范围内日益严重的健康问题,上皮-间充质转化(epithelial-mesenchymal transition,EMT)在NAFLD的纤维化进程中扮演着核心角色.该文将对近年NAFLD中EMT相关作用机制,包括转化生长因子β、微RNA和细胞外囊泡在调节肝脏细胞间的相互作用及纤维化进程中的重要作用作一综述,为开发NAFLD新的治疗策略以及寻找新生物标志物提供方向,尤其是针对EMT过程及其相关分子和信号通路的靶向干预,可能为减缓或逆转纤维化提供有效手段.
Abstract
Non-alcoholic fatty liver disease(NAFLD)is a growing health problem worldwide,and epithelial-mesenchymal transition(EMT)plays a central role in the fibrotic progression of NAFLD.This paper reviewed the mechanism of EMT-related action in NAFLD in recent years,including transforming growth factor-β,micro RNA and extracellular vesicles,which play an important role in regulating the interaction between liver cells and fibrosis process.It provides a direction for researchers for the development of new therapeutic strategies and the research for new biomarkers for NAFLD,especially targeted interventions targeting the EMT process and its related molecules and signaling pathways,which may provide effective means to slow down or reverse fibrosis.
关键词
非酒精性脂肪肝病/上皮-间充质转化/转化生长因子β/肝纤维化Key words
non-alcoholic fatty liver disease/epithelial-mesenchymal transition/transforming growth factor-β/liver fibrosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据