Research status of epithelial-mesenchymal transition in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease(NAFLD)is a growing health problem worldwide,and epithelial-mesenchymal transition(EMT)plays a central role in the fibrotic progression of NAFLD.This paper reviewed the mechanism of EMT-related action in NAFLD in recent years,including transforming growth factor-β,micro RNA and extracellular vesicles,which play an important role in regulating the interaction between liver cells and fibrosis process.It provides a direction for researchers for the development of new therapeutic strategies and the research for new biomarkers for NAFLD,especially targeted interventions targeting the EMT process and its related molecules and signaling pathways,which may provide effective means to slow down or reverse fibrosis.
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