目的 探究粪菌胶囊辅助治疗低风险膜性肾病(membranous nephropathy,MN)对患者的效果及对T细胞亚群及肾功能的影响.方法 选取2022年1月至2024年1月我院收治的低风险MN患者90例,以随机数字表法将其分为对照组和试验组,每组45例.对照组予常规治疗,试验组在其基础上加用粪菌胶囊.比较两组治疗前后肠道菌群分布、菌群失调分级、T淋巴细胞水平、白细胞分化抗原(cluster of differentiation,CD)4+、CD8+、CD4+/CD8+水平及肾功能相关指标.结果 治疗前,两组肠道菌群分布、菌群失调等级、T淋巴细胞、CD4+、CD8+、CD4+/CD8+、肾功能指标水平无显著差异(P＞0.05).治疗后,试验组乳杆菌、拟杆菌、双歧杆菌数量、菌群正常、Ⅰ度失调例数、辅助型T细胞(T helper cell,Th)2、调节性T细胞、CD4+、CD8+、CD4+/CD8+、表皮生长因子受体高于对照组,球杆菌、大肠杆菌数量、Ⅲ度失调例数、Th1、Th17、尿素氮、血肌酐、抗磷脂酶A2受体抗体、Ⅰ型血小板反应蛋白7A水平均低于对照组(P＜0.05).结论 粪菌胶囊辅助治疗低风险MN有助调节肠道菌群平衡,改善细胞T细胞水平和肾功能.
Effects of fecal microbiota capsules in the adjuvant treatment of low-risk membranous nephropathy and its influence on T cell subsets and renal function
Objective To investigate the effects of fecal microbiota capsules in the adjuvant treatment of low-risk membranous nephropathy(MN)and its influence on T cell subsets and renal function.Methods A total of 90 low-risk MN patients admitted to our hospital from January 2022 to January 2024 were selected and divided into control group and experimental group by random number table method,with 45 cases in each group.The control group was treated with routine treatment,and the experimental group was treated with fecal microbiota capsules on the basis of routine treatment.The intestinal flora distribution,flora disorder grade,T lymphocyte level,cluster of differentiation antigen(CD)4+,CD8+,CD4+/CD8+levels and renal function related indexes were compared between the two groups before and after treatment.Results Before treatment,there were no significant differences in intestinal flora distribution,flora disorder grade,T lymphocytes,CD4+,CD8+,CD4+/CD8+and renal function indexes between the two groups(P＞0.05).After treatment,the number of lactobacillus,bacteroides,bifidobacterium,normal flora,number of degree Ⅰ disorder,T helper cell(Th)2,regulatory T cells,CD4+,CD8+,CD4+/CD8+and epidermal growth factor receptor in experimental group were higher than those in control group.The levels of Coccobacillus and Escherichia coli,the number of degree Ⅲ disorders,Th1,Th17,urea nitrogen,serum creatinine,anti-phospholipase A2 receptor antibody and type Ⅰ platelet reactive protein 7A domain were lower than those of control group(P＜0.05).Conclusion Fecal microbiota capsules can help regulate the balance of intestinal flora,improve T cell subsets and renal function in the treatment of low-risk MN.
fecal microbiota capsulelow-risk membranous nephropathyT cell subsetrenal function
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