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慢性支气管炎的炎症相关机制概述

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慢性支气管炎(chronic bronchitis,CB)作为目前广泛存在的一类呼吸系统疾病,其核心发病机制围绕炎症反应展开.这种炎症反应与氧化应激之间形成恶性循环,导致黏液过度分泌、气道表面失水以及气道纤维化重塑等一系列复杂的病理变化.其中各分子机制间相互关联,共同推进疾病的发展.该文综合分析炎症反应在CB中的作用及其引发的多种病理表现,旨在为现有的治疗方法提供改进思路,并激发新型药物的研发灵感,将基础科研成果有效地转化为临床实践,从而为CB患者带来更为有效的治疗策略.
Overview of inflammation-related mechanisms of chronic bronchitis
Chronic bronchitis(CB)is a widespread respiratory disease,and its core pathogenesis revolves around the inflammatory response.A vicious cycle is formed between this inflammatory response and oxidative stress,leading to a series of complex pathological changes such as excessive mucus secretion,airway surface dehydration,and airway fibrosis remodeling.Among them,the molecular mechanisms are interrelated and jointly promote the development of the disease.This article comprehensively analyzed the role of inflammatory response in CB and its various pathological manifestations,aiming to provide improved ideas for existing treatment methods,stimulated the development of new drugs,and effectively transform basic scientific research results into clinical practice,so as to bring more effective treatment strategies for CB patients.

chronic bronchitismolecular mechanisminflammatory reactionoxidative stressmucus high secretion

葛佳宁、顾丰华

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中国医药工业研究总院创新药物与制药工艺国家重点实验室,上海 200437

上海市生物物质成药性评价技术服务平台,上海 200437

慢性支气管炎 分子机制 炎症反应 氧化应激 黏液高分泌

2024

世界临床药物
上海医药工业研究院

世界临床药物

CSTPCD
影响因子:0.849
ISSN:1672-9188
年,卷(期):2024.45(12)