Physicochemical property and percutaneous permeability in vitro of mangiferin liposomes
Objective To investigate the physicochemical property and percutaneous permeability of mangiferin liposomes. Methods Film dispersion method was used to prepare mangiferin liposomes and entrapment efficiency was determined by ultracentrifugation. Particle size and Zeta potential were characterized. Using rat skin as a permeability barrier, accumulation of percutaneous penetration in vitro between mangiferin liposomes and aqueous was compared in Franz diffusion cell. Results The particle size, Zeta potential, and encapsulation efficiency of mangiferin liposomes were (97.7 ± 1.2) nm, (-10.7 ± 0.2) mV, and 44.1%, respectively. The cumulative permeation amount of mangiferin liposome and aqueous was (171.9 ± 13.43) and (102.5 ± 3.97) μg/cm2. Conclusion Liposome delivery system could effectively promote the percutaneous penetration of mangiferin, and provide the experimental reference for new mangiferin transdermal preparations study.
NETL
NSTL
万方数据
维普
