Objective To study the protective effect of lycopene on the myocardial ischemia reperfusion injury (IRI) in SD rat model, and to explore the protective mechanisms.Methods SD rats were randomly divided into Sham, IRI, and lycopene 5, 15 mg/kg + IRI groups. The rats were ig administered with lycopene for 15 d before operation, and the other groups were ig administered with saline, once daily, for 15 d. When the IRI model was established, reperfusion was carried out for 3 h. Then the blood was collected, and the serum levels of related index of myocardial enzymes such as CK and LDH, related indexes of oxidative stress such as SOD and MDA, and relevant indicators of inflammation such as TNF-α and IL-1β were detected. The survivin expression was detected by Western blotting. After 24 h reperfusion, the area of myocardial infarction was detected by Evans blue-TTC double staining method.Results Compared with Sham group, lycopene treatment could significantly decrease the area of myocardial infarction (P< 0.05), significantly decrease the serum levels of CK and LDH (P< 0.05), significantly increase serum level of SOD, but decrease the level of MDA (P< 0.05), and significantly reverse the down-regulated survivin expression induced by IRI (P< 0.05).Conclusion Lycopene has protective effect against myocardial IRI, and its mechanism is not only related to the inhibition of inflammatory and oxidative stress response, but also related to the activation of survivin.
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