Objective To study the clinical efficacy of Shenyi Capsules combined with FOLFOX4 regimen in treatment of gastric cancer.Methods Patients (89 cases) with gastric cancer in Affiliated Hospital of Jianghan University from January 2013 to February 2015 were enrolled in this study. According to the difference treatment plan, patients were divided into the control group (37 cases) and treatment group (52 cases). Patients in the control group were given chemotherapy with FOLFOX4 regimen: Patients were iv administered with Oxaliplatin for injection on day 1, 130 mg/m2, infusion time of 2 h; Patients were iv administered with Calcium Folinate Injection on day 1, 200 mg/m2, infusion time of 2 h. At the same time, patients were iv administered with Fluorouracil Injection on day 1, 300 mg/m2, then changed to iv drip, 600 mg/m2, infusion time of 22 h, 2 weeks for one chemotherapy cycle. Patients with significantly reduced tumors continued one cycle of chemotherapy. Patients in the treatment group werepo administered with Shenyi Capsules on the basis of the control group, 20 mg/time, twice daily, treated for 28 d. After treatment, the clinical efficacies were evaluated, and immune function, serum VEGF levels, and adverse reactions in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 48.6％ and 71.2％, clinical benefit rates were 83.8％ and 96.2％, respectively, and there was difference between two groups (P < 0.05). After treatment, CD3+, CD4+, CD8+, and CD4+/CD8+ in the control group were significantly decreased, but the observational indexes in the treatment group were significantly increased, and there was difference between two groups (P < 0.05). After treatment and 3 months after operation, the serum VEGF levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the serum VEGF level in the treatment group was significantly lower than that in the control group, with significant difference between two groups (P<0.05). The incidence rates of leukopenia, thrombocytopenia, digestive system reaction, and peripheral neurotoxicity in the treatment group were significantly less than those in the control group, and there was difference between two groups (P < 0.05).Conclusion Shenyi Capsules combined with FOLFOX4 regimen has clinical curative effect in the treatment of gastric cancer, and can decrease serum VEGF level, enhance immune function, with good safety, which has a certain clinical application value.
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