Clinical study of levosimendan combined with hydrochlorothiazide in treatment of severe heart failure
Objective To explore the clinical study of levosimendan combined with hydrochlorothiazide in treatment of severe heart failure.Methods A total of 100 patients with severe heart failure admitted to the Intensive Care Unit of Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University from July 2020 to July 2023 were selected and divided into control group and treatment group by random number method,with 50 cases in each group.Patients in the control group were po administered with Hydrochlorothiazide Tablets,50 mg/time,twice daily.Patients in the treatment group were iv administered with Levosimendan Injection on the basis of the control group,5 mL added to 5% glucose injection 500 mL.Both groups were treated for 7 d.The clinical efficacy and improvement time of clinical symptoms in two groups were observed,and the changes of cardiac function index,CQOLI-74 score and serum cytokine level before and after treatment were compared between two groups.Results After treatment,the total effective rate of the treatment group was 98.0% ,which was significantly higher than that of control group(82.0% ,P<0.05).After treatment,the improvement time of dyspnea,fatigue,shortness of breath and lower limb edema in treatment group was shorter than that in the control group(P<0.05).After treatment,left ventricular ejection fraction(LVEF),cardiac output(CO)and GQOLI-74 score in two groups were significantly higher than before treatment(P<0.05).After treatment,LVEF,CO and GQOLI-74 scores in the treatment group were higher than those in control group(P<0.05).After treatment,the levels of β-type brain natriuretic peptide(BNP),soluble growth stimulation expression gene-2 protein(sST2),homocysteine(Hcy)and cystatin C(CysC)in two groups were significantly decreased compared with those before treatment(P<0.05).After treatment,the levels of BNP,sST2,Hcy and CysC in the treatment group were lower than those in control group(P<0.05).Conclusion Levosimendan combined with hydrochlorothiazide has good clinical effect in treatment of severe heart failure,and can effectively improve the clinical symptoms of patients,enhance the index of cardiac function,reduce the inflammatory response of the body,which is worthy of clinical application.
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