Clinical study on Yiqi Fumai(lyophilized)for injection combined with meglumine adenosine cyclophosphate in treatment of chronic heart failure
Objective To investigate the clinical efficacy of Yiqi Fumai(lyophilized)for injection combined with Meglumine Adenosine Cyclophosphate Injection in treatment of chronic heart failure.Methods Patients(216 cases)with chronic heart failure in the First Affiliated Hospital of Henan University from April 2020 to January 2022 were divided into control and treatment groups according to random number tablet method,and each group had 108 cases.Patients in the control group were iv administered with Meglumine Adenosine Cyclophosphate Injection,60—80 mg added into 5% glucose injection 200—500 mL,once daily.Patients in the treatment group were iv administered with Yiqi Fumai(lyophilized)for injection on the basis of the control group,8 bottles added into 5% glucose injection 250—500 mL,once daily.Patients in two groups were treated for 2 weeks.The clinical efficacies,cardiac function indicators,myocardial remodeling indicators,exercise endurance,and serum inflammatory factor indicators in two groups were compared.Results After treatment,the total effective rate of 94.44% in the treatment group was higher than that of 82.41% in the control group(P<0.05).After treatment,LVEF and CO of two groups significantly increased(P<0.05),and LVEF and CO of the treatment group were higher than those of the control group(P<0.05).After treatment,LAP,LVEDD,and LVMI in two groups significantly decreased,while LVRI in two groups significantly increased(P<0.05).LAP,LVEDD,and LVMI in the treatment group were lower than those in the control group,while LVRI in the treatment group was higher than those in the control group(P<0.05).After treatment,6 MWT of two groups significantly increased(P<0.05),and 6 MWT of the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the serum levels of hs-CRP,IL-6,TNF-α,and NT-proBNP in two groups decreased,and the serum levels of hs-CRP,IL-6,TNF-α,and NT-proBNP in the treatment group were lower than those in the control group(P<0.05).Conclusion Yiqi Fumai(lyophilized)for injection combined with Meglumine Adenosine Cyclophosphate Injection has a good effect in the treatment of patients with chronic heart failure,which can effectively improve heart function and myocardial remodeling,and reduce levels of inflammatory factors.
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